Quality Control Of Hydroalcoholic Gels

Résumé: The systematic use of alcohol-based hand sanitizers isthe preferred method to prevent contamination and stop the spread of COVID-19. Increased demand for disinfectants has led to increased prevalence of adulterated alcohol-based disinfectants. The aim of this study is to assess the compliance and effectiveness of alcohol-based hand sanitizers marketed in Algeria. This is a cross-sectional descriptive analytical study, carried out between the month of September and the month of October 2021, on hydro-alcoholic gels samples, randomly selected, present on the market. This work focuses on the qualitative analysis of the labelling and quantitative composition of the disinfectant gels by gas chromatography (GC-FID) to assess their ethanol content and methanol content to prevent the risk of fraud for each of them. As well as the assessment of irritating power by the Draize test. 30 hydro-alcoholic disinfectants were analysed, the average ethanol content of hydro-alcoholic gels was (47.25%±13.85) with a maximum of 79%. 82% of the results obtained do not agree with the who standard. Furthermore, the methanol content in all the hydro-alcoholic gels covered by the study is below the limit of quantification (0.01 g/L). Hand sanitizer with adulterated alcohol is a serious public health risk, especially in the context of the COVID-19 outbreak. The precise determination of ethanol, isopropanol content is the key element in assessing the efficacy and safety of the product.

Publié dans la revue: Journal of Molecular and Pharmaceutical Sciences