Phytochemical Analysis, Anti-inflammatory And Analgesic Properties Of Allium Triquetrum L. In Mice

Résumé: Abstract Description of the subject: Allium triquetrum L. is a spontaneous plant from the Mediterranean basin used in traditional medicine, but rarely studied. Objective : The objective of this study is to evaluate in vivo the anti-inflammatory and analgesic profiles of polar extracts from leaves and bulbs (AqEL, AqEB) of Allium triquetrum L. and its phytochemical analysis. Methods : HPLC-DAD analysis was used to determine the chemical composition of the samples. A preliminary acute toxicity was also studied. The anti-inflammatory activity was assessed using the carrageenan-induced paw edema test and the analgesic effect was examined by the acetic acid-induced writhing model. Results : phytochemical analysis showed the presence of phenolic compounds. Oral administration of extracts at doses up to 2,000 mg/kg did not induce death or toxic symptoms in mice. The treatment with AqEL and AqEB, produced significant dose-dependent inhibition of edema development. The AqEL at the dose of 250 mg/kg exhibited the best anti-inflammatory activity with an edema decrease rate of 59.45%, while the AqEB exhibited a percentage inhibition of 39.45%, at the same concentration. In addition, pretreatment of mice with AqEL, AqEB significantly reduced the number of writhes and the effect was found to be dose-dependent. AqEL and AqEB at the dose of 250 mg/kg reduced the number of writhes with a percentage of analgesia of 72.94% and 52.42%, respectively. Conclusion : The present study suggests that aqueous extracts of A. triquetrum possess potential analgesic and anti-inflammatory effects.

Publié dans la revue: AGROBIOLOGIA